She, along with Kevin, is the guardian of the Michina Town ruins. Like her ancestor Damos, Sheena has the ability to read the hearts of Pokémon. She uses this ability to save Pikachu and Piplup from a water vortex indirectly created by Arceus by praying to Dialga to come save them. She and Kevin are also presumed to have a romantic relationship.

Sheena and Kevin are extremely interested and obsessed in their town's mythology and travel extensively to research it. They were present near the plateau of Alamos Town as it was returned to the proper dimension by Palkia at the end of The Rise of Darkrai and later visited the glacier in Gracidea to see Zero's ship after it crashed during the climax of Giratina and the Sky Warrior.

She explains to Ash and his friends about Dialga's dimension, Palkia's dimension, the Reverse World and Arceus' dimension. She also explains how Arceus saved the world from a meteor and how it gave her ancestor, Damos, the Jewel of Life. She also told them how Damos betrayed Arceus by not returning the Jewel. So as to right the wrongs of her ancestor, she attempted to return the Jewel back to Arceus when it woke up from its long sleep to bring judgment on the world. However the attempt failed since the Jewel apparently was a fake. Dialga then sent her, Ash and co. back to the past to fix it.

After witnessing Damos's betrayal of Arceus, she prayed to Dialga to send them further back in time. They soon met Marcus who invited Sheena to tell him about all the future events. She revealed everything about what will happen and how Damos and Marcus both fail in destroying Arceus and how both fall to their death. This prompts Marcus to think up a different plan and asks Sheena to return the Jewel to Arceus. When Sheena attempts to return the Jewel when Arceus returns, she finds out that Marcus had already taken the Jewel and is now trying to destroy Arceus with "silver water". Damos saves Sheena and they both connect with each other's hearts and they recognize each other. They then connect with all the Pokémon attacking Arceus and compels them to stop their attacks. Sheena, Ash and the others then return back to the future after Arceus saves them. Later they see the engraving on stone that Damos had left for them and Sheena becomes teary-eyed.