Guame the Steady (グァーム, Gwāmu?) is one of the Spiral King's Four Divine Generals, who specialises in ground combat. His appearance is like that of a crocodile and armadillo and he looks the oldest of the four generals. In episode nine, he, along with the two other generals, reported the death of Divine General Thymilph to the Spiral King. He gives off the impression of one with a perverted mind and showed why when he made snide comments about the relationship between Thymilph and General Adiane. Guame appears to merely respect the Spiral King, unlike the other Beastmen, who worship him as a god. Cytomander makes an interesting statement in episode nine, saying that it was only Guame that could oppose the king. Guame merely said that he and the King had known each other for a long time, which gives off the impression that he has lived as long as or almost as long as the Spiral King has (he later referred to General Cytomander as a "two-hundred-years-younger upstart", implying that he is 200 years older than Cytomander). It was Guame who later made it known why Nia was abandoned and that she was not the first princess to be abandoned.

Guame reappears, along with his flagship, the Dai-Gundo. Using Teppelin's power supply, Guame and the Dai-Gundo created a massive tornado, in order to destroy the Great Gurren Brigade and its allies, but his plans are ruined when the Gurren-Lagann tunnels underneath the fortress and impales Guame and the Dai-Gundo into its drill and onto the base of Teppelin.

Guame's name is based on the DNA chemical guanine and the elemental Gnome. His Gunmen, Genber, is based on the mythical Black Tortoise, Genbu.