Misaki Saiki's a very lonely girl. An albino, she was sent over at a young age to live with her father and grandmother. She also had to suffer the taunts of other children because of her unusual appearance. When she got older, she got a job as a dominatrix in one of Tokyo's most notorious S&M clubs. Misaki is used to the various perversions of the male clients she runs into, and is well-trained in how to satisfy their needs. However, this also brings her share of obsessed fans who try to seek her out and stalk her... especially Mitsuru Fujiwara, who constantly sends her text messages on her cell phone.
But a lot of the time, people seek Misaki out because of her ability to talk with the dead. She often works with the city as an exorcist, helping out distressed spirits into going on to the afterlife. She often works with Souichiro Kadotake of the Livelihood Preservation Group, who just happens to be afraid of ghosts, so he's not much help. Working as a professional dominatrix wasn't in Misaki's plan of life, but she doesn't see being a professional medium any different.
Because she's an albino, Misaki usually limits her exposure to direct sunlight because of her fair skin. She also has bad eyesight... not to mention the unusual quirk of being born not having any pubic hair, which can be a turn-on to some of her professional clients, but can cause others to be freaked out if they caught a glimpse of her naked crotch.
(souce: Absolute Anime)